The Hoogenboom Lab

Integrated Light and Electron Microscopy

Integrated microscopes combine the strengths of different instruments into a single system. Integration offers more than the sum of the parts: it allows us to invent, develop, and implement new techniques that cross the boundaries and limitations of existing microscopes. Our lab develops methods and techniques to unravel how molecules and materials function and how this functionality is influenced by the structural environment, in biology, in nanoscience, and in nanophotonics. We aim for impact of our work in science, society, and economy. Therefore we actively collaborate with industry and end users to pursue application of our techniques in the areas of life sciences, health, and materials.
We operate at the interface of light and electron microscopy, of applied and fundamental science, and of physics, engineering, chemistry, and biology.

We are part of the department of Imaging Physics, TU Delft, and form a research section with the labs of Brinks, Carroll, Gheidari, Hagen, and Kruit.
We are a founding group of DEMI - Delft Electron Microscopy Initiative, and are active within NEMI - the Netherlands Electron Microscopy Infrastructure.

Research Topics

Biomolecular Google Maps
​We use integrated microscopy for higher precision and higher (super-)resolution correlative imaging, for higher throughput large-scale microscopy, and to develop faster detectors for (multi-beam) microscopy.

Ultrafast Electron Microscopy
We use integrated microscopy to map the flow of energy at the nanoscale, with time-resolved cathodoluminescence, and ultrafast photon pump electron probe microscopy.  We also use integrated microscopy for live imaging cells.

Light-Electron-Matter Interactions
We use integrated microscopy to study interactions between molecules, photons, and electrons, and to manipulate this interaction for nano-imaging and nano-fabrication.