The Hoogenboom Lab

Integrated Light and Electron Microscopy

We aim to invent, develop, and implement new techniques that cross the boundaries and limitations of existing microscopes in visualizing molecules, molecular functionality, and structural details. Most of our work centers around the combination of light and electron microscopy, physically integrated in a single instrument.  Research topics cover correlative microscopy, superresolution and cathodoluminescence, ultrafast light-electron pump-probe microscopy, multi-scale imaging, and the fundamentals of light-electron-matter interactions. We aim for impact of our work in science, society, and economy. Therefore we actively collaborate with industry and end users to pursue application of our techniques in the areas of life sciences, health, and materials.
We operate at the interface of light and electron microscopy, of applied and fundamental science, and of physics, engineering, chemistry, and biology.

We are part of the department of Imaging Physics, TU Delft, and form a research section with the labs of Brinks, Carroll, Gheidari, Hagen, and Kruit.
We are a founding group of DEMI - Delft Electron Microscopy Initiative, and are active within NEMI - the Netherlands Electron Microscopy Infrastructure.

Research Topics

Biomolecular Google Maps
​We use integrated microscopy for higher precision and higher (super-)resolution correlative imaging, for higher throughput large-scale microscopy, and to develop faster detectors for (multi-beam) microscopy.

Correlative Cryo Electron Microscopy
We use integrated microscopy with coincident electron, ion, and photon beams to localize targets with nanometric resolution in whole frozen hydrated cells for almost atomic scale resolution transmission electron microscopy.

Light-Electron-Matter Interactions
We use integrated microscopy to study interactions between molecules, photons, and electrons, and to manipulate this interaction for nano-imaging and nano-fabrication.